| Nama Liga | : | Superleague Greece | |
| Musim | : | 2021–22 | |
| Assosiasi | : |  Hellenic Football Federation (HFF) | |
| Edisi ke | : | 86th | |
| Tim peserta | : | 14 | |
| Juara bertahan | : | Olympiacos (2020–21) | |
| Tim promosi | : | Ionikos | |
| Total pertandingan | : | 240 | |
| Tanggal pelaksanaan | : | 21 Agustus 2021 – 31 Mei 2022 | |
Musim 2021-22 Superleague Yunani akan menjadi musim ke-86 Superleague Yunani, liga profesional Yunani teratas sejak didirikan pada tahun 1959. Musim ini dimulai pada tanggal 21 Agustus 2021 dan dijadwalkan selesai pada Mei 2022. Olympiakos adalah juara bertahan.
Daftar Tim, Lokasi & Stadion
| Tim | Lokasi | Stadion | Kapasitas |
|---|---|---|---|
 AEK Athens | Athens | Agia Sophia Stadium | 31,800 |
 Apollon Smyrni | Athens | Georgios Kamaras Stadium | 14,200 |
 Aris Thessaloniki | Thessaloniki | Kleanthis Vikelidis Stadium | 23,000 |
 Asteras Tripolis | Tripoli | Theodoros Kolokotronis Stadium | 7,442 |
 Atromitos | Athens | Peristeri Stadium | 10,050 |
 Ionikos | Nikaia | Neapolis Public Stadium | 6,000 |
 Lamia | Lamia | Lamia Municipal Stadium | 5,500 |
 OFI | Heraklion | Theodoros Vardinogiannis Stadium | 9,088 |
 Olympiacos | Piraeus | Georgios Karaiskakis Stadium | 32,115 |
 Panathinaikos | Athens | Apostolos Nikolaidis Stadium | 16,003 |
 Panetolikos | Agrinio | Panetolikos Stadium | 7,321 |
 PAOK | Thessaloniki | Toumba Stadium | 28,703 |
 PAS Giannina | Ioannina | Zosimades Stadium | 7,652 |
 Volos | Volos | Panthessaliko Stadium | 22,700 |
Daftar Sponsor & Produsen Jersey
| Tim | Sponsor | Produsen Jersey |
|---|---|---|
| AEK Athens | Pame Stoixima | Nike |
| Apollon Smyrni | Venetis Bakery | Hummel |
| Aris Thessaloniki | NetBet | Adidas |
| Asteras Tripolis | Volton | Macron |
| Atromitos | NetBet | Capelli |
| Ionikos | Car.gr | Macron |
| Lamia | N/A | Macron |
| OFI | betshop.gr | Puma |
| Olympiacos | Stoiximan | Adidas |
| Panathinaikos | Pame Stoixima | Kappa |
| Panetolikos | Car.gr | Givova |
| PAOK | Stoiximan | Macron |
| PAS Giannina | NetBet | Le Coq Sportif |
| Volos | EBOL | Luanvi |
Daftar Pelatih
| Tim | Manager/Pelatih | Kebangsaan | |
|---|---|---|---|
| AEK Athens | Argirios Giannikis | Yunani | |
| Apollon Smyrni | Marco Grote |  Jerman | |
| Aris Thessaloniki | Akis Mantzios | Yunani | |
| Asteras Tripolis | Milan Rastavac |  Serbia | |
| Atromitos | Chris Coleman |  Wales | |
| Ionikos | Dimitrios Spanos | Yunani | |
| Lamia | Michalis Grigoriou | Yunani | |
| OFI | Nikos Nioplias | Yunani | |
| Olympiacos | Pedro Martins |  Portugal | |
| Panathinaikos | Ivan Jovanović | Serbia | |
| Panetolikos | Yannis Anastasiou | Yunani | |
| PAOK | Răzvan Lucescu |  Rumania | |
| PAS Giannina | Iraklis Metaxas | Yunani | |
| Volos | Konstantinos Bratsos (caretaker) | Yunani | |
Daftar Kapten Tim
| Tim | Nama Kapten | Kebangsaan |
|---|---|---|
| AEK Athens | Petros Mantalos | Yunani |
| Apollon Smyrni | Christos Lisgaras | Yunani |
| Aris Thessaloniki | Georgios Delizisis | Yunani |
| Asteras Tripolis | Matías Iglesias |  Argentina |
| Atromitos | Kyriakos Kivrakidis | Yunani |
| Ionikos | Alaixys Romao |  Togo |
| Lamia | Loukas Vyntra | Yunani |
| OFI | Nikos Korovesis | Yunani |
| Olympiacos | Kostas Fortounis | Yunani |
| Panathinaikos | Dimitris Kourbelis | Yunani |
| Panetolikos | Jorge Díaz |  Uruguay |
| PAOK | Vieirinha | Portugal |
| PAS Giannina | Stefanos Siontis | Yunani |
| Volos | Tasos Tsokanis | Yunani |
Tabel Klasemen
| Pos. | Tim | Main | M | S | K | MG | KG | SG | Poin |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Olympiacos | 26 | 20 | 5 | 1 | 47 | 14 | 33 | 65 |
| 2 | PAOK | 26 | 16 | 5 | 5 | 50 | 24 | 26 | 53 |
| 3 | AEK Athens | 26 | 14 | 4 | 8 | 42 | 28 | 14 | 46 |
| 4 | Aris Thessaloniki | 26 | 13 | 6 | 7 | 28 | 21 | 7 | 45 |
| 5 | Panathinaikos | 26 | 13 | 3 | 10 | 41 | 21 | 20 | 42 |
| 6 | OFI | 26 | 9 | 10 | 7 | 33 | 32 | 1 | 37 |
| 7 | PAS Giannina | 26 | 11 | 7 | 8 | 28 | 24 | 4 | 35 |
| 8 | Asteras Tripolis | 26 | 10 | 5 | 11 | 27 | 29 | -2 | 35 |
| 9 | Panetolikos | 26 | 9 | 5 | 12 | 27 | 39 | -12 | 32 |
| 10 | Volos | 26 | 8 | 6 | 12 | 35 | 42 | -7 | 30 |
| 11 | Ionikos | 26 | 6 | 8 | 12 | 26 | 34 | -8 | 26 |
| 12 | Atromitos | 26 | 6 | 5 | 15 | 27 | 47 | -20 | 23 |
| 13 | Lamia | 26 | 4 | 6 | 16 | 19 | 37 | -18 | 18 |
| 14 | Apollon Smyrni | 26 | 2 | 7 | 17 | 9 | 47 | -38 | 13 |
